Ask a Librarian: COVID-19 (updated regularly)

Testing for COVID-19

Last updated: February 5, 2021 - Originally published: February 10, 2020

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Joule’s Ask a Librarian team has committed its skills to curate free evidence-based resources related to the current COVID-19 pandemic. This page will be updated regularly – the information and resources added most recently will be marked with an asterisk (*).

Visit the CMA’s COVID-19 page for public health information and resources for physicians and patients. 

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Clinical summaries

DynaMed

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COVID-19 (Novel Coronavirus) – Updated Jan 19, 2021

Description

  • global pandemic of acute respiratory disease caused by a novel coronavirus (SARS-CoV-2) 1
  • SARS-CoV-2 is a member of beta genus coronaviruses closely related to SARS-CoV (Nat Microbiol 2020 Mar 2 early online)
  • common signs of COVID-19 include fever, cough, and shortness of breath1
  • there is no specific antiviral treatment for COVID-19, but supportive care may help to relieve symptoms and should include support of vital organ functions in severe cases1

Recent selected updates 

  • 19 Jan 2021: people with COVID-19 are at high risk of developing severe illness and potential exposure to this virus needs to be limited for patients with pulmonary conditions; pulmonary rehabilitation (PR) programs should offer education on and reinforce best practices to reduce risk of COVID-19 infection (Canadian Journal of Respiratory, Critical Care, and Sleep Medicine 2020) View in topic

  • 12 Jan 2021: COVID-19 mRNA nucleoside modified vaccine (COVID-19 Vaccine Moderna dispersion for injection) authorized for temporary supply by United Kingdom Department of Health and Social Care and Medicines and Healthcare products Regulatory Agency (MHRA) for active immunization to prevent COVID-19 disease caused by SARS-CoV-2 in persons ≥ 18 years old (United Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA) Information for UK Healthcare Providers 2021 Jan 8, MHRA Press Release 2021 Jan 8) View in topic

  • 11 Jan 2021: CHOSEN risk score may help predict suitability for discharge based on risk of hypoxia, admission to intensive care, and death within 14 days in adults with COVID-19 (J Gen Intern Med 2020 Dec 3 early online) View in topic

  • 11 Jan 2021: seropositivity associated with reduced risk of SARS-CoV-2 reinfection in healthcare workers followed for 6 months (N Engl J Med 2020 Dec 23 early online) View in topic

  • 11 Jan 2021: bamlanivimab may not improve recovery at 90 days in adults hospitalized with COVID-19 without end-organ failure (N Engl J Med 2020 Dec 22 early online) View in topic

  • 8 Jan 2021: Moderna mRNA vaccine (mRNA-1273) may be 94% effective against COVID-19 in adults (N Engl J Med 2020 Dec 30 early online) View in topic

  • 8 Jan 2021: COVID-19 mRNA vaccine nucleoside modified (COVID-19 Vaccine Moderna dispersion for injection) receives conditional marketing authorization by the European Commission for active immunization to prevent COVID-19 in persons ≥ 18 years old, with the following specific considerations for administration in Europe (European Medicines Agency [EMA] Press Release 2021 Jan 6) View in topic

  • 6 Jan 2021: 83,326,479 confirmed cases of COVID-19 including 1,831,703 deaths worldwide reported by World Health Organization (WHO) as of January 3, 2021 (WHO Weekly Epidemiological Update 2021 Jan 5) View in topic

  • 6 Jan 2021: 2 standard doses of adenovirus-vectored vaccine expressing SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) may be 62% effective against COVID-19 in adults (Lancet 2020 Dec 8 early online) View in topic

  • 6 Jan 2021: COVID-19 Vaccine (ChAdOx1-S [recombinant]) (COVID-19 Vaccine AstraZeneca) authorized for temporary supply by United Kingdom Department of Health and Social Care and MHRA for active immunization to prevent COVID-19 disease caused by SARS-CoV-2 virus in persons ≥ 18 years old (United Kingdom MHRA Press Release 2020 Dec 30) View in topic

  • 6 Jan 2021: mRNA-1273 SARS-CoV-2 Vaccine (Moderna COVID-19 Vaccine) receives authorization under interim order by Health Canada for use in persons ≥ 18 years old for active immunization to prevent COVID-19 (Health Canada Press Release 2020 Dec 23) View in topic

  • 6 Jan 2021: COVID-19 mRNA Vaccine BNT162b2 authorized for temporary supply by United Kingdom Department of Health and Social Care and MHRA for active immunization to prevent COVID-19 disease caused by SARS-CoV-2 in persons ≥ 16 years old (United Kingdom MHRA Information for UK Healthcare Professionals 2020 Dec 31) View in topic

  • 4 Jan 2021: results of lateral flow serological assays may change or become unreadable from 15 minutes to 24 hours after sampling (Lancet Respir Med 2020 Sep) View in topic

Topic Summary (CMA members can access all full summaries via this link)

DynaMed COVID-19 related summaries

BMJ Best Practice

Coronavirus disease 2019 (COVID-19) – Last reviewed December 13, 2020. This topic last updated: January 19, 2021.

 

UpToDate

Coronavirus disease 2019 (COVID-19) – Literature review current through December 2020. This topic last updated: January 11, 2021.

 

Essential Evidence Plus

Coronavirus SARS-CoV2 infection (COVID-19) – This topic last updated: November 25, 2020.

 

Canadian Pharmacists Association

COVID-19 – Information for primary care practitioners on the management of common symptoms and a summary of experimental treatments being used in acute-care settings. This topic last updated: June 25, 2020.

 

Clinical information via ClinicalKey

ClinicalKey drives better care by delivering fast, concise answers, and deep access to evidence whenever, wherever you need it. ClinicalKey includes access to 1,000+ textbooks, 600 full-text journals, images, videos and customizable patient handouts across 30+ medical specialties

Novel Coronavirus Information Center  (Elsevier/ClinicalKey) - freely available and current information in English and Mandarin Chinese. Updated: January 15, 2021.

In ClinicalKey (CMA members only), search “COVID-19” for the latest articles from The Lancet, International Journal of Infectious Diseases, Journal of Infection and more.

Procedural Videos - Orotracheal Intubation (login required).

Book chapters:

Gerber  Novel Coronavirus from Wuhan China, 2019-20, Update to Chapter 155, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Ninth Edition (Elsevier, 2020). 

Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Chapter 155, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Ninth Edition (Elsevier, 2020).

 

Evidence syntheses

CADTH COVID-19 evidence portal – Canadian Agency for Drugs and Technologies in Health. Updated December 15, 2020. Accessed January 19, 2021.

Centre for Evidence-Based Medicine Oxford University – COVID-19 evidence service. Updated January 18, 2021. Accessed January 19, 2021.

Coronavirus Disease 2019 (COVID-19) Daily Research Briefs – American Family Physician. Updated January 19, 2021. Accessed January 19, 2021. 

COVID-19: a living systematic map of the evidence - EPPI Centre. Updated January 14, 2021. Accessed January 19, 2021.

COVID-19 Evidence Alerts – weekly update of high-quality clinical studies curated by McMaster University. Free email notification is available upon registration. Last updated January 19, 2021. Accessed January 19, 2021.

COVID-19 Evidence Network to support Decision-making (COVID-END) – McMaster University – No date. Accessed January 19, 2021.

COVID-19 Evidence Reviews –VA Evidence Synthesis Program. Updated January 15, 2021. Accessed January 19, 2021.

COVID-19 research briefs - Essential Evidence Plus – Joule, A CMA Company. Updated December 27, 2020. Accessed January 19, 2021.

Evidence aid ‒ Coronavirus (COVID-19) – summaries of relevant research. Updated January 18, 2021. Accessed January 19, 2021.

REAL – COVID-19 Rapid Evidence Resource Link – Dala Lana School of Public Health – University of Toronto. Updated January 12, 2021. Accessed January 19, 2021.

 

Articles, article collections and reviews

Annals of Internal Medicine - Coronavirus Disease 2019 (COVID-19).

BMJ - Coronavirus (COVID-19) hub – collection of freely available news articles, opinion and timeline.

Cambridge University Press – Coronavirus Free Access Collection. 

CMAJ – COVID-19 – CMAJ articles, podcasts and blogs on public health and policy.

Elsevier Vaccines Toolkit – latest evidence-based information about vaccines approved for use to prevent COVID-19 infections. 

Epocrates COVID-19 Drug Therapy Trial Updates – links to trials and resources focused on therapeutics. 

JAMA Coronavirus Disease 2019 (COVID-19) – collection of current articles and multimedia.

The Lancet COVID-19 Resource Centre – free access to COVID-19 content from across The Lancet journals.

Merck Manuals COVID-19 Information and Resources – news, commentary and FAQs.

New England Journal of Medicine – Coronavirus (COVID-19) – collection of articles and other resources on the 2019 Novel Coronavirus outbreak including clinical reports, management guidelines and commentary (Chinese translations available for some content).

Oxford University Press – free access to OUP resources on COVID-19, other coronaviruses and related topics. 

Springer-Nature - Coronavirus (COVID-19) Research Highlights. 

Wiley Online Library - Covid-19: Novel Coronavirus Outbreak. 

Wolters Kluwer COVID-19 Resources & Tools (Coronavirus Resources) – updates and articles. 

 

Guidelines and other information

International 

Coronavirus (COVID-19) – National Institute for Health and Care Excellence (UK). No date.  Accessed  January 19, 2021.

Caring for people with COVID-19 – National COVID-19 Clinical Evidence Taskforce (Australia). Last updated January 17, 2021. Accessed January 19, 2021. 

Coronavirus Disease 2019 (COVID-19): information for health care professionals – Centers for Disease Control and Prevention. Last reviewed December 28, 2020. Accessed January 19, 2021. 

Interactive, global map tracking COVID-19 – Johns Hopkins University. Updated January 19, 2021. Accessed January 19, 2021.

Coronavirus disease (COVID-19) pandemic – World Health Organization. Updated January 18, 2021. Accessed January 19, 2021.

Coronavirus disease - European Centre for Disease Prevention and Control. Updated January 15, 2021. Accessed January 19, 2021. 

Penn Medicine COVID-19  Guidance Summaries - University of Pennsylvania Center for Evidence-based Practice. Updated December 24, 2020. Accessed January 19, 2021.

Global Coronavirus COVID-19 Clinical Trial Tracker - world map of clinical trials. Last updated December 23, 2020. Accessed January 19, 2021. 

 

National 

Clinical guideline search (CPG Infobase) – Joule, A Canadian Medical Association Company. Clinical Practice Guidelines on COVID-19/Coronavirus infections. Updated December 18, 2020. Accessed January 19, 2021.

CMA update: COVID-19 – Canadian Medical Association No date. Accessed January 19, 2021.

COVID-19 resources- Canadian Institute for Health Information.  Last updated December 10, 2020. Accessed January 15, 2021.

COVID-19 – Choosing Wisely Canada. Last updated April 30, 2020. Accessed December 14, 2020.

COVID-19 A data perspective – Statistics Canada. Last updated January 19, 2021. Accessed January 19, 2021.

COVID-19 Information and Resources – College of Family Physicians of Canada. No date. Accessed January 19, 2021.

COVID-19 Resource Centre  – The Centre for Effective Practice. Updated December 2020.  Accessed January 19, 2021.

Coronavirus disease (COVID-19): Outbreak update – Government of Canada. Updated January 18, 2021. Accessed January 19, 2021.

Coronavirus disease (COVID-19): For health professionals – Government of Canada. Updated January 18, 2021. Accessed January 19, 2021.

Coronavirus infection: Symptoms and treatment – Government of Canada. Updated  January 18, 2021. Accessed January 19, 202`.

Coronavirus (COVID-19) SARS-CoV-2 – Infection Prevention and Control Canada. Updated January 19, 2021. Accessed January 19, 2021.

Infection prevention and control for coronavirus disease (COVID-19): Second interim guidance for acute healthcare settings  – Public Health Agency of Canada. Updated January 8, 2021. Accessed January 19, 2021.

 

Provincial

British Columbia:

Yukon: COVID-19 information  – Government of Yukon. Updated January 19, 2021.  Accessed January 19, 2021.

Northwest Territories: COVID-19 in NWT – Government of Northwest Territories – Health and Social Services. Updated January 18, 2021. Accessed January 19, 2021.

Alberta: Novel Coronavirus (COVID-19) – Alberta Health Services. Updated January 18, 2021. Accessed January 19, 2021.

Saskatchewan: COVID-19 – Saskatchewan. No date. Accessed January 15, 2021.

Manitoba: 

Nunavut: COVID-19 (Novel Coronavirus) – Nunavut Department of Health. Updated January 19, 2021.  Accessed January 19, 2021.

Ontario:

Quebec: 

COVID-19. (content in French) - Institut national d’excellence en santé et en services sociaux. Updated December 30, 2020. Accessed January 19, 2021. New Brunswick:  Coronavirus – Office of the Chief Medical Officer of Health (Public Health) New Brunswick. No date. Accessed January 19, 2021.

Nova Scotia: 

Prince Edward Island: COVID-19 – Prince Edward Island Health and Wellness. No Date. Accessed January 19, 2021. 

Newfoundland: NLife with COVID-19  – Newfoundland Health and Community Services. Updated January 15, 2021. Accessed January 19, 2021. 

 

Webinars and podcasts 

BMJ Best Practice Podcasts – BMJ Best Practice – No date. Accessed January 19, 2021.

Coronavirus (COVID19) – American Medical Association ED Hub. No date. Accessed January 19, 2021.

TEACH. ENGAGE. APPLY (CUPA-TEA) COVID-10 webinar series - Association of Medical Microbiology and Infectious Disease (AMMI) Canada – Updated December 3, 2020. Accessed January 19, 2021.

COVID-19 Podcasts – CMAJ Podcasts. No date. Accessed January 19, 2021.

COVID-19 Podcasts and Webinars - Center for Infectious Disease Research and Policy, University of Minnesota. Updated January 14, 2021. Accessed January 19, 2021.

COVID-19 Webinars – College of Family Physician of Canada. No date. Accessed January 19 , 2021.

Clinical Management Through COVID-19 Webinar Series Recordings – Harvard Medical School. Updated November 2, 2020. Accessed January 19, 2021.

Coronavirus videos – The JAMA Network. Updated January 19, 2021. Accessed January 19, 2021.

Joule COVID-19 Learning Series – Joule, A Canadian Medical Association Company – No date. Accessed January 19, 2021.

What’s Next COVID-19 Podcast – University of Toronto. Updated December 17, 2020. Accessed January 19, 2021.

COVID-19 Webinars – University of Toronto Faculty of Medicine. No date. Accessed January 19, 2021.

Covid-19/Covid-19 webinars – Guidelines International Network. Updated November 9, 2020. Accessed January 19, 2021.

 

Telemedicine and virtual care 

Virtual Care Playbook – Canadian Medical Association, The College of Family Physicians, and Royal College of Physicians and Surgeons of Canada. March 30, 2020. Accessed January 19, 2021.

Virtual care guide for patients - Canadian Medical Association, The College of Family Physicians, and Royal College of Physicians and Surgeons of Canada. June 2020. Accessed January 19, 2021.

Telemedicine and virtual care guidelines (and other clinical resources for COVID-19) – Royal College of Physicians and Surgeons of Canada. Updated July 6, 2020. Accessed January 19, 2021.

Telehealth and virtual care – Canadian Medical Protective Association. No date. Accessed February 5, 2021.

Virtual care: Resources for health care workers during COVID-19 – Centre for Addiction and Mental Health. No date. Accessed February 5, 2021.

Enablers for virtual visits – CADTH – Updated September 4, 2020. Accessed January 19, 2021.

Rapid response to COVID-19 – Canada Health Infoway. No date. Accessed January 19, 2021.

Canada’s Virtual Care Revolution: A Framework for Success – C.D. Howe Institute. December 8, 2020. Accessed February 5, 2021.

Virtual care is here to stay  – Ontario MD. No date. Accessed January 19, 2021.

Virtual Care- Toolkit – Doctors of BC. Updated November 6, 2020. Accessed January 19, 2021.

COVID-19: Virtual Care - College of Physicians & Surgeons of Alberta. Updated November 2020. Accessed January 19, 2021.

 

Ethics and medical-legal resources

Framework for Ethical Decision Making During the Coronavirus Pandemic – Canadian Medical Association. Updated April 1, 2020. Accessed January 19, 2021.

COVID-19 Hub – advice, support, and medical-legal protection during the COVID-19 pandemic – Canadian Medical Protective Association. Updated December 23, 2020. Accessed January 19, 2021.

Ethics – BC Centre for Disease Control. Last updated January 19, 2021.  Accessed January 19, 2021.

Public Health Ethics and COVID-19: Selected Resources – National Collaborating Centre for Healthy Public Policy/ Institut national de santé publique (Québec).  Last updated: December, 2020. Accessed January 19, 2021.

Ethics Resources on the Coronavirus (COVID-19) - collection of articles and reports on ethics related to COVID-19, other coronaviruses and pandemics – Hastings Center. No date. Accessed January 19, 2021.

 

Patient education resources

COVID-19 Resources and Tools for the public – Canadian Medical Association.  No date. Accessed January 19, 2021.

My COVID-19 Visit Risk - Ryerson University National Institute on Ageing (NIA) - understand the risks associated with your planned visit, and tips on how to make any proposed visits as safe as possible. Accessed January 19, 2021.

Questions and answers on COVID-19 – Canadian Medical Association, the College of Family Physicians of Canada and the Royal College of Physicians and Surgeons of Canada. Updated January 18, 2021. Accessed January 19, 2021.

Symptoms checklist: COVID-19, cold and flu – How do they compare? - CanadianHealthcareNetwork.ca - compiled from the Public Health Agency of Canada, the U.S. Centers for Disease Control and the World Health Organization. September 7, 2020. Accessed January 19, 2021.

What you should know about COVID-19 to protect yourself and others  – Centers for Disease Control and Prevention. Updated June 1, 2020. Accessed January 19, 2021.

Prevent the spread of COVID-19 if you are sick   – Centers for Disease Control and Prevention. August 11, 2020. Accessed January 19, 2021.

Coronavirus Disease (COVID-19): Awareness resources (fact sheets and infographics available in many languages) – Public Health Agency of Canada. Updated January 8, 2021. Accessed January 19, 2021.

 

Databases and pre-populated literature searches 

COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv  

COVID-19 global literature on coronavirus disease - World Health Organization

Cochrane Library - Coronavirus (COVID-19) – evidence relevant to critical care.

Coronavirus disease (COVID‑19) - Epistemonikos foundation L·OVE database.

COVID-19 Live Literature Searches - Australian Library and Information Association.

COVID-19 primer – Powered by Primer (AI) – dashboard for latest research and trending news and articles. 

LitCovid – the US National Library of Medicine’s curated literature hub for tracking up-to-date scientific information about the virus.

GoogleScholar search

Pubmed search

Trip database search (Turning research into practice)

 

Need more information or have a more focused clinical question on coronaviruses or any other clinical topic of interest? Contact the Ask a Librarian team to request a literature search.

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This material is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. The opinions stated by the authors are made in a personal capacity and do not necessarily reflect those of the Canadian Medical Association and its subsidiaries including Joule.

 

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