Ask a Librarian: COVID-19 (updated regularly)

Testing for COVID-19

Last updated: April 8, 2021 - Originally published: February 10, 2020

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CMA Joule’s Ask a Librarian team has committed its skills to curate free evidence-based resources related to the current COVID-19 pandemic. This page will be updated regularly – the information and resources added most recently will be marked with an asterisk (*).

Visit the CMA’s COVID-19 page for public health information and resources for physicians and patients. 

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Clinical summaries

DynaMed

Access DynaMed online or through the mobile app to get concise overviews and detailed recommendations, medical graphics and images, drug information from Micromedex and more.

COVID-19 (Novel Coronavirus) – Updated April 7, 2021

Description

  • global pandemic of acute respiratory disease caused by a novel coronavirus (SARS-CoV-2) 1
  • SARS-CoV-2 is a member of beta genus coronaviruses closely related to SARS-CoV (Nat Microbiol 2020 Mar 2 early online)
  • common signs of COVID-19 include fever, cough, and shortness of breath1
  • there is no specific antiviral treatment for COVID-19, but supportive care may help to relieve symptoms and should include support of vital organ functions in severe cases1

Recent selected updates *

  • 5 Apr 2021: rapid point-of-care antigen tests may have high specificity but low sensitivity for detection of SARS-CoV-2 infection (Cochrane Database Syst Rev 2021 Mar 24). View in topic
  • 1 Apr 2021: about 80%-83% protection against reinfection with SARS-CoV-2 reported in persons < 65 years old, and 47% protection against reinfection reported in adults ≥ 65 years old in Denmark (Lancet 2021 Mar 27) View in topic
  • 1 Apr 2021: in adults with laboratory-confirmed COVID-19, estimated peak prevalence of IgM antibodies about 80% with peak levels at about 20 days after symptom onset, and peak prevalence of IgG antibodies 95% with peak levels at about 25 days (Ann Intern Med 2021 Mar 16 early online). View in topic
  • 1 Apr 2021: 6.9% seroprevalence of pan-immunoglobulins against SARS-CoV-2 in spring 2020 in Wuhan, China, with seroconversion to neutralizing antibodies in about 64% of persons with symptoms compared to 35% of persons without symptom (Lancet 2021 Mar 20) View in topic
  • 30 Mar 2021: 2-dose regimen of ChAdOx1 nCoV-19 vaccine may not be effective against mild-to-moderate Covid-19 due to B.1.351 variant in adults ≤ 64 years old (N Engl J Med 2021 Mar 16 early online) View in topic
  • 30 Mar 2021: living with children and adolescents associated with increased risk of SARS-CoV-2 infection and related hospitalization in adults ≤ 65 years old and increased risk of infection and related ICU admission and death in adults (BMJ 2021 Mar 18) View in topic
  • 23 Mar 2021: EMA safety committee concludes that benefits of vaccination with AstraZeneca ChAdOx-1-S COVID-19 vaccine outweigh risks despite rare cases of thrombosis associated with thrombocytopenia (EMA Press Release 2021 Mar 18) View in topic
  • 23 Mar 2021: 51% of patients hospitalized with COVID-19 reported symptoms 4 months after discharge from hospital or intensive care (JAMA 2021 Mar 17 early online) View in topic
  • 18 Mar 2021:SCARP score may help predict risk of progression to severe disease or death within 7 days in adults hospitalized with moderate COVID-19 (Ann Intern Med 2021 Mar 2 early online) View in topic
  • 17 Mar 2021: infection with SARS-CoV-2 variant of concern 202012/1 associated with increased 28-day mortality (BMJ 2021 Mar 9) View in topic
  • 11 Mar 2021: Ad26.COV2.S, recombinant (Janssen COVID-19 Vaccine) receives authorization under interim order by Health Canada for use in persons ≥ 18 years old for active immunization to prevent COVID-19, with the following specific considerations for immunization in Canada (Health Canada Press Release 2021 Mar 5) View in topic
  • 9 Mar 2021: ≥ 12-week interval between 2 standard doses of ChAdOx1 nCoV-19 vaccine may be 81% effective and < 6-week interval may be 55% effective to prevent COVID-19 in adults (Lancet 2021 Feb 19 early online) View in topic

Topic Summary (CMA members can access all full summaries via this link)

DynaMed COVID-19 related summaries

BMJ Best Practice

Coronavirus disease 2019 (COVID-19) – This topic last updated: March 26, 2021.

 

UpToDate

Coronavirus disease 2019 (COVID-19) – Literature review current through March 2021. This topic last updated: March 31, 2021.

 

Essential Evidence Plus

Coronavirus SARS-CoV2 infection (COVID-19) – This topic last updated: March 15, 2021.

 

Canadian Pharmacists Association

 

COVID-19 – Information for primary care practitioners on the management of common symptoms and a summary of experimental treatments being used in acute-care settings. This topic last updated: June 25, 2020.

CPS Web (CMA members only) – Search “COVID-19” to access drug monographs and patient drug information for AstraZeneca, Janssen, Moderna, and PFIZER-BIONTECH COVID-19 vaccines. *

 

Clinical information via ClinicalKey

ClinicalKey drives better care by delivering fast, concise answers, and deep access to evidence whenever, wherever you need it. ClinicalKey includes access to 1,000+ textbooks, 600 full-text journals, images, videos and customizable patient handouts across 30+ medical specialties

Novel Coronavirus Information Center  (Elsevier/ClinicalKey) - freely available and current information in English and Mandarin Chinese. Updated: April 2, 2021.

In ClinicalKey (CMA members only), search “COVID-19” for the latest articles from The Lancet, International Journal of Infectious Diseases, Journal of Infection and more.

Procedural Videos - Orotracheal Intubation (login required).

Book chapters:

Novel Coronavirus from Wuhan China, 2019-20, Update to Chapter 155, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Ninth Edition (Elsevier, 2020). 

Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Chapter 155, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Ninth Edition (Elsevier, 2020).

 

Evidence syntheses

American Family Physician - Coronavirus Disease 2019 (COVID-19) Daily Research Briefs. Updated April 7, 2021. Accessed April 7, 2021. 

Canadian Agency for Drugs and Technologies in Health - CADTH COVID-19 evidence portal. Updated April 1, 2021. Accessed April 7, 2021.

Centre for Evidence-Based Medicine Oxford University – Oxford COVID-19 evidence service. Updated March 19, 2021. Accessed April 7, 2021.

Dala Lana School of Public Health, University of Toronto - REAL – COVID-19 Rapid Evidence Access Link – Updated March 22, 2021. Accessed April 7, 2021.

EPPI Centre - COVID-19: a living systematic map of the evidence - Updated March 25, 2021. Accessed April 7, 2021.

Essential Evidence Plus. CMA Joule  -  COVID-19 research briefs (Archive). *New in 2021* Selected COVID-19 research briefs are published as part of the regular POEMs schedule. Updated December 27, 2020. Accessed April 7, 2021.

Evidence aid ‒ Coronavirus (COVID-19) – summaries of relevant research. Updated April 7, 2021. Accessed April 7, 2021.

McMaster University - COVID-19 Evidence Alerts – weekly update of high-quality clinical studies. Free email notification is available upon registration. Last updated April 7, 2021. April 7, 2021.

McMaster University - COVID-19 Evidence Network to support Decision-making (COVID-END) No date. Accessed April 7, 2021.

VA Evidence Synthesis Program - COVID-19 Evidence Reviews . Updated April 7, 2021. Accessed April 7, 2021.

 

Articles, article collections and reviews

Annals of Internal Medicine - Coronavirus Disease 2019 (COVID-19).

BMJ - Coronavirus (COVID-19) hub – collection of freely available news articles, opinion and timeline.

Cambridge University Press – Coronavirus Free Access Collection. 

CMAJ – COVID-19 – CMAJ articles, podcasts and blogs on public health and policy.

cmajOPEN – COVID-19 – collection of COVID-19 research articles. *

Elsevier Vaccines Toolkit – latest evidence-based information about vaccines approved for use to prevent COVID-19 infections. 

Epocrates COVID-19 Drug Therapy Trial Updates – links to trials and resources focused on therapeutics. 

JAMA Coronavirus Disease 2019 (COVID-19) – collection of current articles and multimedia.

The Lancet COVID-19 Resource Centre – free access to COVID-19 content from across The Lancet journals.

Merck Manuals COVID-19 Information and Resources – news, commentary and FAQs.

New England Journal of Medicine – Coronavirus (COVID-19) – collection of articles and other resources on the 2019 Novel Coronavirus outbreak including clinical reports, management guidelines and commentary (Chinese translations available for some content).

Oxford University Press – free access to OUP resources on COVID-19, other coronaviruses and related topics. 

Springer-Nature - Coronavirus (COVID-19) Research Highlights. 

Wiley Online Library - Covid-19: Novel Coronavirus Outbreak. 

Wolters Kluwer COVID-19 Resources & Tools (Coronavirus Resources) – updates, articles and podcasts. 

 

Guidelines and other information

International 

Centers for Disease Control and Prevention -  Coronavirus Disease 2019 (COVID-19): information for health care workers. Last reviewed March 31, 2021. Accessed April 7, 2021. 

Cytel (biostatistics) - Global Coronavirus COVID-19 Clinical Trial Tracker - world map of clinical trials. Last updated April 5, 2021. Accessed April 7, 2021. 

European Centre for Disease Prevention and Control - Coronavirus disease. Updated April 7, 2021. Accessed April 7, 2021. 

Johns Hopkins University - Interactive, global map tracking COVID-19. Updated April 7, 2021. Accessed April 7, 2021.

National COVID-19 Clinical Evidence Taskforce (Australia) - Caring for people with COVID-19. Last updated April 1, 2021. Accessed April 7, 2021. 

National Institute for Health and Care Excellence (UK) - Coronavirus (COVID-19) No date.  Accessed April 7, 2021.

University of Pennsylvania Center for Evidence-based Practice - COVID-19  Guidance Summaries. Updated March 31, 2021. Accessed April 7, 2021.

World Health Organization - Coronavirus disease (COVID-19) pandemic. Updated April 7, 2021. Accessed April 7, 2021.

National 

Canadian Institute for Health Information - COVID-19 resources.  Last updated March 30, 2021. Accessed April 7, 2021.

Canadian Institutes of Health Research (CIHR) - COVID19 Recommendations and Gateway to Contextualization. Updated April 7, 2021. Accessed April 8, 2021. *

Boldly (by Canadian Medical Association) - Ask a Librarian: COVID-19 vaccines and the immunization roll-out. Updated March 8, 2021. Accessed April 8, 2021. *

Canadian Medical Association - CMA update: COVID-19 – No date. Accessed April 7, 2021.

Centre for Effective Practice - COVID-19 Resource Centre. Updated April 2021.  Accessed April 7, 2021.

Choosing Wisely Canada - COVID-19. No date. Accessed April 7, 2021.

CMA Joule - Clinical guideline search (CPG Infobase). Clinical Practice Guidelines on COVID-19/Coronavirus infections. Updated April 2, 2021. Accessed April 7, 2021.

College of Family Physicians of Canada - COVID-19 Information and Resources. Updated March 18, 2021. Accessed April 7, 2021.

Government of Canada - Coronavirus disease (COVID-19): For health professionals. Updated February 17, 2021. Accessed April 7, 2021.

Government of Canada - Coronavirus disease (COVID-19): Outbreak update. Updated April 6, 2021. Accessed April 7, 2021.

Government of Canada - Coronavirus infection: Symptoms and treatment. Updated March 22, 2021. Accessed April 7, 2021.

Infection Prevention and Control Canada - Coronavirus (COVID-19) SARS-CoV-2. Updated April 7, 2021. Accessed April 7, 2021.

Public Health Agency of Canada - Infection prevention and control for coronavirus disease (COVID-19): Second interim guidance for acute healthcare settings. Updated February 12, 2021. Accessed April 7, 2021.

Statistics Canada - COVID-19 A data perspective. Last updated April 7, 2021. Accessed April 7, 2021.

Provincial

British Columbia:

Yukon: Government of Yukon - COVID-19 information. Updated April 7, 2021.  Accessed April 7, 2021.

Northwest Territories: Government of Northwest Territories – Health and Social Services - COVID-19 in NWT. Updated April 6, 2021. Accessed April 7, 2021.

Alberta: Alberta Health Services - COVID-19 Information for Albertans). Updated April 6, 2021. Accessed April 7, 2021.

Saskatchewan: Saskatchewan -  COVID-19. No date. Accessed April 7, 2021.

Manitoba: 

Nunavut: Nunavut Department of Health - COVID-19 (Novel Coronavirus) –. Updated April 7, 2021.  Accessed April 7, 2021.

Ontario:

Quebec:

New Brunswick:  Office of the Chief Medical Officer of Health (Public Health) New Brunswick - Coronavirus. No date. Accessed April 7, 2021.

Nova Scotia:

Prince Edward Island: Prince Edward Island Health and Wellness - COVID-19. Updated April 6, 2021. Accessed April 7, 2021. 

Newfoundland: Newfoundland Health and Community Services - NLife with COVID-19. Updated April 7, 2021. Accessed April 7, 2021. 

 

Webinars and podcasts 

American Medical Association ED Hub -  Coronavirus (COVID19). No date. Accessed April 7, 2021.

Association of Medical Microbiology and Infectious Disease (AMMI) Canada - TEACH. ENGAGE. APPLY (CUPA-TEA) COVID-10 webinar series. Updated December 3, 2020. Accessed April 7, 2021.

BMJ Best Practice - BMJ Best Practice Podcasts. No date. Accessed April 7, 2021.

Center for Infectious Disease Research and Policy, University of Minnesota -  COVID-19 Podcasts and Webinars. Updated April 1, 2021. Accessed April 7, 2021.

CMA Joule -  COVID-19 Learning Series. No date. Accessed April 8, 2021.

CMAJ Podcasts -  COVID-19 Podcasts. No date. Accessed April 7, 2021.

College of Family Physician of Canada - COVID-19 Webinars. Updated March 23, 2021. Accessed April 7, 2021.

Elsevier - Expert Insights on COVID-19 podcasts. No date. Accessed April 8, 2021. *

Harvard Medical School - Clinical Management Through COVID-19 Webinar Series Recordings. Updated November 2, 2020. Accessed April 8, 2021.

The JAMA Network -  Coronavirus videos. Updated March 25, 2021. Accessed April 8, 2021.

University of Toronto - What’s Next COVID-19 Podcast. Updated December 17, 2020. Accessed April 8, 2021.

University of Toronto Faculty of Medicine - COVID-19 Webinars. No date. Accessed April 8, 2021.

 

Telemedicine and virtual care 

CADTH - Enablers for virtual visits. Updated September 4, 2020. Accessed April 8, 2021.

Canada Health Infoway -  Rapid response to COVID-19. Updated January 2021. Accessed April 8, 2021.

Canadian Medical Association, The College of Family Physicians, and Royal College of Physicians and Surgeons of Canada -  Virtual care guide for patients. June 2020. Accessed April 8, 2021.

Canadian Medical Association, The College of Family Physicians, and Royal College of Physicians and Surgeons of Canada -  Virtual Care Playbook. March 30, 2020. Accessed April 8, 2021.

Canadian Medical Protective Association -  Telehealth and virtual care. No date. Accessed April 8, 2021.

C.D. Howe Institute - Canada’s Virtual Care Revolution: A Framework for Success. December 8, 2020. Accessed April 8, 2021.

Centre for Addiction and Mental Health Virtual care: Resources for health care workers during COVID-19. No date. Accessed April 8, 2021.

College of Family Physicians of Canada - Virtual Care in the Patient’s Medical Home. February 2021. Accessed April 8, 2021. *

College of Physicians & Surgeons of Alberta -  COVID-19: Virtual Care. Updated November 2020. Accessed April 8, 2021.

Doctors of BC - Virtual Care- Toolkit. Updated February 23, 2021. Accessed April 8, 2021.

Ontario MD - Virtual care is here to stay. No date. Accessed April 8, 2021.

Royal College of Physicians and Surgeons of Canada -  Telemedicine and virtual care guidelines (and other clinical resources for COVID-19). Updated July 6, 2020. Accessed April 8, 2021.

 

Ethics and medical-legal resources

BC Centre for Disease Control - Ethics. Last updated January 19, 2021.  Accessed April 8, 2021.

Canadian Medical Association - Framework for Ethical Decision Making During the Coronavirus Pandemic. Updated April 1, 2020. Accessed April 8, 2021.

Canadian Medical Protective Association - COVID-19 Hub – advice, support, and medical-legal protection during the COVID-19 pandemic. Updated February 19, 2021. Accessed April 8, 2021.

Hastings Center - Ethics Resources on the Coronavirus (COVID-19) - collection of articles and reports on ethics related to COVID-19, other coronaviruses and pandemics. No date. Accessed April 8, 2021.

National Collaborating Centre for Healthy Public Policy/ Institut national de santé publique (Québec) - Public Health Ethics and COVID-19: Selected Resources.  Last updated: March 2021. Accessed April 8, 2021.

 

Patient education resources

Canadian Medical Association, the College of Family Physicians of Canada and the Royal College of Physicians and Surgeons of Canada - Questions and answers on COVID-19. Updated March 16, 2021. Accessed April 8, 2021.

Canadian Medical Association - COVID-19 Resources and Tools for the public.  No date. Accessed April 8, 2021.

CanadianHealthcareNetwork.ca - compiled from the Public Health Agency of Canada, the U.S. Centers for Disease Control and the World Health Organization -  Symptoms checklist: COVID-19, cold and flu – How do they compare?. September 7, 2020. Accessed April 8, 2021.

Centers for Disease Control and Prevention - Prevent the spread of COVID-19 if you are sick. August 11, 2020. Accessed April 8, 2021.

Centers for Disease Control and Prevention - What you should know about COVID-19 to protect yourself and others. Updated March 17, 2021. Accessed April 8, 2021.

Public Health Agency of Canada - Coronavirus Disease (COVID-19): Awareness resources (fact sheets and infographics available in many languages). Updated March 9, 2021. Accessed April 8, 2021.

Ryerson University National Institute on Ageing (NIA) -  My COVID-19 Visit Risk  - understand the risks associated with your planned visit, and tips on how to make any proposed visits as safe as possible. Accessed April 8, 2021.

 

Databases and pre-populated literature searches

COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv  

COVID-19 global literature on coronavirus disease - World Health Organization

Cochrane Library - Coronavirus (COVID-19) – evidence relevant to critical care.

Coronavirus disease (COVID‑19) - Epistemonikos foundation L·OVE database.

COVID-19 Live Literature Searches - Australian Library and Information Association.

COVID-19 primer – Powered by Primer (AI) – dashboard for latest research and trending news and articles. 

LitCovid – the US National Library of Medicine’s curated literature hub for tracking up-to-date scientific information about the virus.

GoogleScholar search

Pubmed search

Trip database search (Turning research into practice)

 

Need more information or have a more focused clinical question on coronaviruses or any other clinical topic of interest? Contact the Ask a Librarian team to request a literature search.

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This material is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. The opinions stated by the authors are made in a personal capacity and do not necessarily reflect those of the Canadian Medical Association and its subsidiaries including Joule.

 

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